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Article

Structure/function aspects of human 3beta-hydroxysteroid dehydrogenase.

Molecular and cellular endocrinology - 27 Feb 2004

Thomas James L, Duax William L, Addlagatta Anthony, Kacsoh Balint, Brandt Stacey E, Norris Wendy B

Abstract excerpt

Separate genes encode the human type 1 (placenta, breast tumors, other peripheral tissues) and type 2 (gonad, adrenal) isoforms of 3 beta-hydroxysteroid dehydrogenase/isomerase (3 beta-HSD1, 3 beta-HSD2). Mutagenesis of 3 beta-HSD1 produced the Y154F, H156Y and K158Q mutant enzymes in the probable Y(154)-P-H(156)-S-K(158) catalytic motif. The H(156)Y mutant of the 3 beta-HSD1 created a chimera of the 3 beta-HSD2...

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Identifiers

PMID: 15026177
DOI: 10.1016/j.mce.2003.11.018

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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