Article
Hemostatic gene polymorphisms in severe acute pancreatitis.
Pancreas - 1 Mar 2009
Tukiainen Eija, Kylänpää Marja-Leena, Repo Heikki, Orpana Arto, Methuen Taina, Salaspuro Mikko, Kemppainen Esko, Puolakkainen Pauli
Abstract excerpt
OBJECTIVE: Systemic inflammatory reaction in acute pancreatitis (AP) is associated with activation of the coagulation system. The prothrombotic component of the coagulation system, which may promote microvascular thrombosis and vital organ injury, is strengthened by genetic factors such as polymorphism of plasminogen activator inhibitor type 1 (PAI-1) and factor V Leiden (FVL) mutation. This prompted us to study...
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