Article
Is the monocyte chemotactic protein-1 -2518 G allele a risk factor for severe acute pancreatitis?
Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association - 1 May 2005
Papachristou Georgios I, Sass David A, Avula Haritha, Lamb Janette, Lokshin Anna, Barmada M Michael, Slivka Adam, Whitcomb David C
Abstract excerpt
BACKGROUND & AIMS: Acute pancreatitis (AP) reflects the intensity of the inflammatory response and is divided into mild AP (MAP) or severe AP (SAP). Monocyte chemotactic protein-1 (MCP-1) gene expression is altered by an A/G polymorphism (-2518), with the G allele increasing MCP-1 production. Our aim was to determine whether the MCP-1 -2518 A/G polymorphism affects the severity of AP. METHODS: Seventy-seven...
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