Article
Analysis of the hierarchy of quorum-sensing regulation in Pseudomonas aeruginosa.
Analytical and bioanalytical chemistry - 1 Jan 2007
Wagner Victoria E, Li Luen-Luen, Isabella Vincent M, Iglewski Barbara H
Abstract excerpt
Quorum-sensing in Pseudomonas aeruginosa is known to regulate several aspects of pathogenesis, including virulence factor production, biofilm development, and antimicrobial resistance. Recent high-throughput analysis has revealed the existence of several layers of regulation within the QS-circuit. To address this complexity, mutations in genes encoding known or putative transcriptional regulators that were also...
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