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Article

PDGFRA, PDGFRB, EGFR, and downstream signaling activation in malignant peripheral nerve sheath tumor.

Neuro-oncology - 1 Dec 2009

Perrone Federica, Da Riva Luca, Orsenigo Marta, Losa Marco, Jocollè Genny, Millefanti Clara, Pastore Elisa, Gronchi Alessandro, Pierotti Marco Alessandro, Pilotti Silvana

Abstract excerpt

We investigated the activation of platelet-derived growth factor (PDGF) receptor A (PDGFRA), PDGF receptor B (PDGFRB), epidermal growth factor receptor (EGFR), and their downstream pathways in malignant peripheral nerve sheath tumors (MPNSTs). PDGFRA, PDGFRB, and EGFR were immunohistochemically, biochemically, cytogenetically, and mutationally analyzed along with the detection of their cognate ligands in 16...

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Share to Extracellular Signal-Regulated MAP Kinases
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Nerve Sheath Neoplasms

Share to Proto-Oncogene Proteins c-ret

Share to PTEN Phosphohydrolase

Share to Receptor, Platelet-Derived Growth Factor alpha

Share to Receptor, Platelet-Derived Growth Factor beta

Share to TOR Serine-Threonine Kinases

Source

Open in PubMed Open full text

Identifiers

PMID: 19246520
DOI: 10.1215/15228517-2009-003
PMCID: PMC2802393

Genes

EGFR
PDGFRA
PDGFRB
PTEN
BRAF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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