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Article

CD133+CD24lo defines a 5-Fluorouracil-resistant colon cancer stem cell-like phenotype.

Oncotarget - 29 Nov 2016

Paschall Amy V, Yang Dafeng, Lu Chunwan, Redd Priscilla S, Choi Jeong-Hyeon, Heaton Christopher M, Lee Jeffrey R, Nayak-Kapoor Asha, Liu Kebin

Abstract excerpt

The chemotherapeutic agent 5-Fluorouracil (5-FU) is the most commonly used drug for patients with advanced colon cancer. However, development of resistance to 5-FU is inevitable in almost all patients. The mechanism by which colon cancer develops 5-FU resistance is still unclear. One recently proposed theory is that cancer stem-like cells underlie colon cancer 5-FU resistance, but the phenotypes of 5-FU-resistant...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 27659530
DOI: 10.18632/oncotarget.12168
PMCID: PMC5346671

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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