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Article

Human colon cancer stem cells are enriched by insulin-like growth factor-1 and are sensitive to figitumumab

15 Jul 2011

Abstract excerpt

Cancer stem cells (CSCs) are recognized as contributors to cancer progression and therapeutic resistance in liquid and solid malignancies. We analyzed a panel of human colon cancer cell lines for CSC populations by side population and aldehyde dehydrogenase activity. IGF-1 enriches these putative colon CSC populations in a β-catenin-dependent manner. Chemical inhibition of Akt depletes SP cells, and conversely,...

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PMID: 21720213
DOI: 10.4161/cc.10.14.16418

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