Analysis of families with Lynch syndrome complicated by advanced serrated neoplasia: the importance of pathology review and pedigree analysis.

doi:10.1007/s10689-009-9238-8

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Article

Analysis of families with Lynch syndrome complicated by advanced serrated neoplasia: the importance of pathology review and pedigree analysis.

Familial cancer - 1 Jan 2009

Walsh Michael D, Buchanan Daniel D, Walters Rhiannon, Roberts Aedan, Arnold Sven, McKeone Diane, Clendenning Mark, Ruszkiewicz Andrew R, Jenkins Mark A, Hopper John L, Goldblatt Jack, George Jillian, Suthers Graeme K, Phillips Kerry, Young Graeme P, Macrae Finlay, Drini Musa, Woods Michael O, Parry Susan, Jass Jeremy R, Young Joanne P

Abstract excerpt

The identification of Lynch syndrome has been greatly assisted by the advent of tumour immunohistochemistry (IHC) for mismatch repair (MMR) proteins, and by the recognition of the role of acquired somatic BRAF mutation in sporadic MMR-deficient colorectal cancer (CRC). However, somatic BRAF mutation may also be present in the tumours in families with a predisposition to develop serrated polyps in the colorectum....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 19241144
DOI: 10.1007/s10689-009-9238-8
PMCID: PMC2783449

Genes

MLH1
BRAF
MSH2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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