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Article

Significant associations of mismatch repair gene polymorphisms with clinical outcome of pancreatic cancer.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 1 Apr 2009

Dong Xiaoqun, Jiao Li, Li Yanan, Evans Douglas B, Wang Huamin, Hess Kenneth R, Abbruzzese James L, Li Donghui

Abstract excerpt

PURPOSE: DNA mismatch repair (MMR) is critical in maintaining genomic stability and may modulate the cellular response to gemcitabine. We hypothesized that genetic variations in MMR may affect the clinical outcome of patients with pancreatic cancer. PATIENTS AND METHODS: We evaluated 15 single-nucleotide polymorphisms (SNPs) of eight MMR genes in 154 patients with potentially resectable pancreatic adenocarcinoma...

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Source

Open in PubMed Open full text

Identifiers

PMID: 19237629
DOI: 10.1200/JCO.2008.20.1111
PMCID: PMC2668967

Genes

TREX1
EXO1
MLH1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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