Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Gain-of-function ADAMTS13 variants that are resistant to autoantibodies against ADAMTS13 in patients with acquired thrombotic thrombocytopenic purpura.

Blood - 19 Apr 2012

Jian Cui, Xiao Juan, Gong Lingjie, Skipwith Christopher G, Jin Sheng-Yu, Kwaan Hau C, Zheng X Long

Abstract excerpt

Thrombotic thrombocytopenic purpura (TTP) is primarily caused by immunoglobulin G (IgG) autoantibodies against A Disintegrin And Metalloprotease with ThromboSpondin type 1 repeats, 13 (ADAMTS13). Nearly all adult idiopathic TTP patients harbor IgGs, which bind the spacer domain of ADAMTS13, a region critical for recognition and proteolysis of von Willebrand factor (VWF). We hypothesize that a modification of an...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to ADAM Proteins
Share to ADAMTS13 Protein

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Antibody Specificity

Share to Autoantibodies

Share to Binding Sites, Antibody

Share to Immunoglobulin G

Share to Immunotherapy

Share to Purpura, Thrombotic Thrombocytopenic

Source

Open in PubMed Open full text

Identifiers

PMID: 22289888
DOI: 10.1182/blood-2011-12-399501
PMCID: PMC3335387

Genes

ADAMTS13
VWF

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Gain-of-function ADAMTS13 variants that are resistant to autoantibodies against ADAMTS13 in patients with acquired thrombotic thrombocytopenic purpura.PMID 22289888Read ↗

Inherited ADAMTS13 mutations associated with Thrombotic Thrombocytopenic Purpura: a short review and update.Semantic proximity Read ↗

ADAMTS13 and anti-ADAMTS13 autoantibodies in thrombotic thrombocytopenic purpura - current perspectives and new treatment strategies.Semantic proximity Read ↗

ADAMTS-13 cysteine-rich/spacer domains are functionally essential for von Willebrand factor cleavage.Semantic proximity Read ↗

Role of ADAMTS13 in the pathogenesis, diagnosis, and treatment of thrombotic thrombocytopenic purpura.Semantic proximity Read ↗

Novel ADAMTS-13 mutations in an adult with delayed onset thrombotic thrombocytopenic purpura.Semantic proximity Read ↗

Insights into 3D Structure of ADAMTS13: A Stepping Stone towards Novel Therapeutic Treatment of Thrombotic Thrombocytopenic Purpura.Semantic proximity Read ↗

Current and Future Perspectives on ADAMTS13 and Thrombotic Thrombocytopenic Purpura.Semantic proximity Read ↗

ADAMTS13 turns 3.Semantic proximity Read ↗

In vitro characterization of a novel Arg102 mutation in the ADAMTS13 metalloprotease domain.Semantic proximity Read ↗

Novel ADAMTS13 mutations in a patient with congenital thrombotic thrombocytopenic purpura.Semantic proximity Read ↗

Essential role of the disintegrin-like domain in ADAMTS13 function.Semantic proximity Read ↗

ADAMTS13 gene defects in two brothers with constitutional thrombotic thrombocytopenic purpura and normalization of von Willebrand factor-cleaving protease activity by recombinant human ADAMTS13.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.