Article
Austronesian origin of the 27-bp deletion of the erythrocyte band 3 gene in East Sepik, Papua New Guinea inferred from mtDNA analysis.
Journal of human genetics - 1 Jan 2006
Tsukahara Takahiro, Hombhanje Francis Wanak, Lum Jeffrey Koji, Hwaihwanje Ilomo, Masta Andrew, Kaneko Akira, Kobayakawa Takatoshi
Abstract excerpt
The 27-bp deletion in the erythrocyte band 3 gene (B3Delta27) constitutes a genetic basis for Southeast Asian and Melanesian ovalocytosis. The distribution of B3Delta27 has been interpreted to reflect malaria selection or dispersal of the recent expansion of Austronesian-speaking populations. To explore these two hypotheses, we examined eight malarious populations of the East Sepik Province of Papua New Guinea...
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