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Article

Effect of smoking and CYP2D6 polymorphisms on the extent of fluvoxamine-alprazolam interaction in patients with psychosomatic disease.

European journal of clinical pharmacology - 1 Jul 2009

Sugahara Hideyo, Maebara Chiharu, Ohtani Hisakazu, Handa Masanori, Ando Katsumi, Mine Kazunori, Kubo Chiharu, Ieiri Ichiro, Sawada Yasufumi

Abstract excerpt

PURPOSE: Fluvoxamine (FVX) is metabolized by cytochrome P450 (CYP) 2D6 and CYP1A2 and inhibits CYP3A4. The aim of this study was to investigate the factors responsible for interindividual variability in the extent of interaction between FVX and alprazolam (ALP). METHODS: Blood samples were taken from 49 depressive patients to determine plasma concentration of FVX, ALP or both. Twenty-four samples were taken...

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Identifiers

PMID: 19225771
DOI: 10.1007/s00228-009-0629-4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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