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Article

Effects of concomitant fluvoxamine on the metabolism of alprazolam in Japanese psychiatric patients: interaction with CYP2C19 mutated alleles.

European journal of clinical pharmacology - 1 Apr 2003

Suzuki Yutaro, Shioiri Toshiki, Muratake Tatsuyuki, Kawashima Yoshiaki, Sato Satoshi, Hagiwara Mieko, Inoue Yoshimasa, Shimoda Kazutaka, Someya Toshiyuki

Abstract excerpt

OBJECTIVES: Administration of fluvoxamine (FLV) with concomitant benzodiazepines is common in clinical situations. We studied the effects of the coadministration of FLV on plasma concentrations of alprazolam (ALP). We also studied the effects of CYP2C19(*)2 or CYP2C19(*)3 on these drug interactions. METHODS: The subjects were 23 Japanese outpatients all concomitantly treated with FLV either before or after...

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Identifiers

PMID: 12698310
DOI: 10.1007/s00228-003-0563-9

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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