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Article

Essential role of one-carbon metabolism and Gcn4p and Bas1p transcriptional regulators during adaptation to anaerobic growth of Saccharomyces cerevisiae.

The Journal of biological chemistry - 24 Apr 2009

Tsoi Bonny M, Beckhouse Anthony G, Gelling Cristy L, Raftery Mark J, Chiu Joyce, Tsoi Abraham M, Lauterbach Lars, Rogers Peter J, Higgins Vincent J, Dawes Ian W

Abstract excerpt

The transcriptional activator Gcn4p is considered the master regulator of amino acid metabolism in Saccharomyces cerevisiae and is required for the transcriptional response to amino acid starvation. Here it is shown that Gcn4p plays a previously undescribed role in regulating adaptation to anaerobic growth. A gcn4 mutant exhibited a highly extended lag phase after a shift to anaerobiosis that was the result of...

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Identifiers

PMID: 19224916
DOI: 10.1074/jbc.M809225200
PMCID: PMC2670125

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