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Article

Mutation screening of HSF4 in 150 age-related cataract patients.

Molecular vision - 1 Jan 2008

Shi Yuefeng, Shi Xiaohe, Jin Yiping, Miao Aizhu, Bu Lei, He Jianyong, Jiang Haisong, Lu Yi, Kong Xiangyin, Hu Landian

Abstract excerpt

PURPOSE: Heat shock transcription factor 4 (HSF4) regulates the expression of several heat shock protein (HSP) genes. HSPs are one of the major components responsible for lens protein organization. Recently, we found that mutations of HSF4 result in hereditary cataract. In this study, we explore the role of HSF4 in the development of age-related cataract. METHODS: We screened sequence variants of HSF4 in...

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Source

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Identifiers

PMID: 18941546
PMCID: PMC2569895

Genes

HSF4

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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