Article
Human immunodeficiency virus type 1 isolates with the reverse transcriptase (RT) mutation Q145M retain nucleoside and nonnucleoside RT inhibitor susceptibility.
Antimicrobial agents and chemotherapy - 1 May 2009
Varghese Vici, Mitsuya Yumi, Shahriar Rajin, Bachmann Michael H, Fessel W Jeffrey, Kagan Ron M, Shafer Robert W
Abstract excerpt
Q145M, a mutation in a conserved human immunodeficiency virus type 1 reverse transcriptase (RT) region, was reported to decrease susceptibility to multiple RT inhibitors. We report that Q145M and other Q145 mutations do not emerge with RT inhibitors nor decrease RT inhibitor susceptibility. Q145M should not, therefore, be considered an RT inhibitor resistance mutation.
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