Article
Gln145Met/Leu changes in human immunodeficiency virus type 1 reverse transcriptase confer resistance to nucleoside and nonnucleoside analogs and impair virus replication.
Antimicrobial agents and chemotherapy - 1 Dec 2004
Paolucci Stefania, Baldanti Fausto, Maga Giovanni, Cancio Reynel, Zazzi Maurizio, Zavattoni Maurizio, Chiesa Antonella, Spadari Silvio, Gerna Giuseppe
Abstract excerpt
The frequencies of multidrug resistance-associated mutations at codons 145, 151, and 69 of the human immunodeficiency virus (HIV) reverse transcriptase (RT) gene in strains from a group of 3,595 highly active antiretroviral therapy (HAART)-experienced patients were 0.22, 2.36, and 0.86%, respectively. Several amino acid substitutions different from the recently reported Gln145Met change (S. Paolucci, F. Baldanti,...
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