Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Suppression of Tumor Growth<i>In vivo</i>by the Mitocan α-tocopheryl Succinate Requires Respiratory Complex II

18 Feb 2009

Abstract excerpt

PURPOSE: Vitamin E analogues are potent novel anticancer drugs. The purpose of this study was to elucidate the cellular target by which these agents, represented by alpha-tocopoheryl succinate (alpha-TOS), suppress tumors in vivo, with the focus on the mitochondrial complex II (CII). EXPERIMENTAL DESIGN: Chinese hamster lung fibroblasts with functional, dysfunctional, and reconstituted CII were transformed using...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antioxidant Activity and Oxidative Stress
Share to Cancer, Hypoxia, and Metabolism
Share to Retinoids in leukemia and cellular processes

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 19223492
DOI: 10.1158/1078-0432.ccr-08-2439

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 8 closest

Suppression of Tumor Growth<i>In vivo</i>by the Mitocan α-tocopheryl Succinate Requires Respiratory Complex IIPMID 19223492Read ↗

Abolishing respiratory complex I decreases in vivo growth of high grade serous ovarian cancer cells and sensitizes to anti-angiogenic therapySemantic proximity Read ↗

Mitochondrial dysfunction impairs tumor suppressor p53 expression/function.Semantic proximity Read ↗

Effects of <em>Sutherlandia Frutescens</em> on Cancer and Primary Cells during Chemotherapy and Chemotherapy Induced Cellular SenescenceSemantic proximity Read ↗

Respiration-Deficient Cells Require Pyruvate Carboxylase to Suppress Asparagine AuxotrophySemantic proximity Read ↗

Role of reactive oxygen species in the induction of apoptosis by α‐tocopheryl succinateSemantic proximity Read ↗

Cellular vitamin C increases chromate toxicity via a death program requiring mismatch repair but not p53.Semantic proximity Read ↗

Differential KEAP1/NRF2 mediated signaling widens the therapeutic window of redox-targeting drugs in SCLC therapySemantic proximity Read ↗

Targeted Anti-Mitochondrial Therapy: The Future of OncologySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.