Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genetic control of RNA splicing and its distinct role in complex trait variation.

Nature genetics - 1 Sept 2022

Qi Ting, Wu Yang, Fang Hailing, Zhang Futao, Liu Shouye, Zeng Jian, Yang Jian

Abstract excerpt

Most genetic variants identified from genome-wide association studies (GWAS) in humans are noncoding, indicating their role in gene regulation. Previous studies have shown considerable links of GWAS signals to expression quantitative trait loci (eQTLs) but the links to other genetic regulatory mechanisms, such as splicing QTLs (sQTLs), are underexplored. Here, we introduce an sQTL mapping method, testing for...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Genetic Variation
Share to Genome-Wide Association Study
Share to Multifactorial Inheritance

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Polymorphism, Single Nucleotide

Share to Quantitative Trait Loci

Share to RNA Splicing

Source

Open in PubMed Open full text

Identifiers

PMID: 35982161
DOI: 10.1038/s41588-022-01154-4
PMCID: PMC9470536

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genetic control of RNA splicing and its distinct role in complex trait variation.PMID 35982161Read ↗

Genetic control of RNA splicing and its distinctive role in complex trait variationSemantic proximity Read ↗

Identification of common genetic variants controlling transcript isoform variation in human whole blood.Semantic proximity Read ↗

Identification and analysis of splicing quantitative trait loci across multiple tissues in the human genome.Semantic proximity Read ↗

Identification and analysis of splicing quantitative trait loci across multiple tissues in the human genomeSemantic proximity Read ↗

Regional Variation of Splicing QTLs in Human Brain.Semantic proximity Read ↗

Mapping genetic effects on splicing in ten thousand post-mortem brain samples reveals novel mediators of neurological disease riskSemantic proximity Read ↗

RNA splicing is a primary link between genetic variation and disease.Semantic proximity Read ↗

A Deep Dive into Statistical Modeling of RNA Splicing QTLs Reveals New Variants that Explain Neurodegenerative DiseaseSemantic proximity Read ↗

Integrating Whole Genome and Transcriptome Sequencing to Characterize the Genetic Architecture of Isoform Variation and its Implications for Health and DiseaseSemantic proximity Read ↗

Isoform-level transcriptome-wide association uncovers extensive novel genetic risk mechanisms for neuropsychiatric disorders in the human brainSemantic proximity Read ↗

Tissue-specific genetic control of splicing: implications for the study of complex traits.Semantic proximity Read ↗

A deep dive into statistical modeling of RNA splicing QTLs reveals variants that explain neurodegenerative disease.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.