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Article

MiR-34, SIRT1, and p53: The feedback loop

1 Mar 2009

Abstract excerpt

MicroRNAs (miRNAs) are small non-coding RNAs that regulate gene expression. Several studies have linked dysregulation of miRNA with tumorigenesis. The TP53 is one of the most commonly mutated genes in human cancers, and its gene product p53 activates transcription of a set of miRNA including the miR-34 family of miRNA. The miR-34 family regulates cell cycle progression, cellular senescence and apoptosis, but the...

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PMID: 19221490
DOI: 10.4161/cc.8.5.7753

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