Article
Founder population-specific HapMap panel increases power in GWA studies through improved imputation accuracy and CNV tagging.
Genome research - 1 Oct 2010
Surakka Ida, Kristiansson Kati, Anttila Verneri, Inouye Michael, Barnes Chris, Moutsianas Loukas, Salomaa Veikko, Daly Mark, Palotie Aarno, Peltonen Leena, Ripatti Samuli
Abstract excerpt
The combining of genome-wide association (GWA) data across populations represents a major challenge for massive global meta-analyses. Genotype imputation using densely genotyped reference samples facilitates the combination of data across different genotyping platforms. HapMap data is typically used as a reference for single nucleotide polymorphism (SNP) imputation and tagging copy number polymorphisms (CNPs)....
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