Article
Ubiquitin ligase Cbl-b sensitizes leukemia and gastric cancer cells to anthracyclines by activating the mitochondrial pathway and modulating Akt and ERK survival signals.
FEBS letters - 7 Jul 2009
Qu Xiujuan, Zhang Ye, Li Yingchun, Hu Xuejun, Xu Yingying, Xu Ling, Hou Kezou, Sada Kiyonao, Liu Yunpeng
Abstract excerpt
The present study reported that the ubiquitin ligase Cbl-b was up-regulated during anthracycline-induced apoptosis in two cell lines, RBL-2H3 leukemia cells and MGC803 gastric cancer cells. Overexpression of Cbl-b strongly promoted the cytotoxic and apoptosis-inducing effects of anthracyclines, w...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.