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Article

Targeting aberrant PI3K/Akt activation by PI103 restores sensitivity to TRAIL-induced apoptosis in neuroblastoma.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 May 2011

Opel Daniela, Naumann Ivonne, Schneider Maxi, Bertele Daniela, Debatin Klaus-Michael, Fulda Simone

Abstract excerpt

PURPOSE: Because we recently identified Akt activation as a novel poor prognostic indicator in neuroblastoma, we investigated whether phosphoinositide 3'-kinase (PI3K) inhibition sensitizes neuroblastoma cells for TRAIL-induced apoptosis. EXPERIMENTAL DESIGN: The effect of pharmacological or genetic inhibition of PI3K or mTOR was analyzed on apoptosis induction, clonogenic survival, and activation of apoptosis...

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PMID: 21355080
DOI: 10.1158/1078-0432.CCR-10-2530

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XIAP

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