Article
Lack of linkage and association of adrenomedullin and its receptor genes in French Caucasian rheumatoid arthritis trio families.
Clinical and experimental rheumatology - 1 Jan 2000
Michou L, Garnier S, Barbet S, Glikmans E, Ea H-K, Uzan B, Asensio C, Ah Kioon M-D, Lasbleiz S, Bardin T, Cornélis F, Lioté F
Abstract excerpt
OBJECTIVE: Rheumatoid arthritis (RA) is characterized by hyperplasia of fibro-blast-like synoviocytes (FLSs), in part due to apoptosis resistance. Adrenomedullin, an anti-apoptotic peptide, is secreted more by RA than osteoarthritis FLSs. Adrenomedullin binds to a heterodimeric functional recepto...
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