Article
Loss of yata, a novel gene regulating the subcellular localization of APPL, induces deterioration of neural tissues and lifespan shortening.
PloS one - 1 Jan 2009
Sone Masaki, Uchida Atsuko, Komatsu Ayumi, Suzuki Emiko, Ibuki Ikue, Asada Megumi, Shiwaku Hiroki, Tamura Takuya, Hoshino Mikio, Okazawa Hitoshi, Nabeshima Yo-ichi
Abstract excerpt
BACKGROUND: The subcellular localization of membrane and secreted proteins is finely and dynamically regulated through intracellular vesicular trafficking for permitting various biological processes. Drosophila Amyloid precursor protein like (APPL) and Hikaru genki (HIG) are examples of proteins that show differential subcellular localization among several developmental stages. METHODOLOGY/PRINCIPAL FINDINGS:...
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