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Integrin β4 Regulates SPARC Protein to Promote Invasion

4 Feb 2012

Abstract excerpt

The α6β4 integrin (referred to as "β4" integrin) is a receptor for laminins that promotes carcinoma invasion through its ability to regulate key signaling pathways and cytoskeletal dynamics. An analysis of published Affymetrix GeneChip data to detect downstream effectors involved in β4-mediated invasion of breast carcinoma cells identified SPARC, or secreted protein acidic and rich in cysteine. This glycoprotein...

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PMID: 22308039
DOI: 10.1074/jbc.m111.317727

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