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The Prefusogenic Intermediate of HIV-1 gp41 Contains Exposed C-peptide Regions

1 Feb 2003

Abstract excerpt

The human immunodeficiency virus type 1 (HIV-1) envelope glycoprotein is composed of a complex between the surface subunit gp120, which binds to cellular receptors, and the transmembrane subunit gp41. Upon activation of the envelope glycoprotein by cellular receptors, gp41 undergoes conformational changes that mediate fusion of the viral and cellular membranes. Prior to formation of a fusogenic...

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PMID: 12486032
DOI: 10.1074/jbc.m211154200

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