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Article

Modulation of fatty acid synthase enzyme activity and expression during hepatitis C virus replication.

Chemistry & biology - 18 Apr 2013

Nasheri Neda, Joyce Michael, Rouleau Yanouchka, Yang Pengyu, Yao Shao, Tyrrell D Lorne, Pezacki John Paul

Abstract excerpt

The hepatitis C virus (HCV) induces alterations of host cells to facilitate its life cycle. Fatty acid synthase (FASN) is a multidomain enzyme that plays a key role in the biosynthesis of fatty acids and is upregulated during HCV infection. Herein, we applied activity-based protein profiling (ABPP) that allows for the identification of differentially active enzymes in complex proteomic samples, to study the...

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Identifiers

PMID: 23601646
DOI: 10.1016/j.chembiol.2013.03.014

Genes

FASN

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