Article
Fluorescence detection of single-nucleotide polymorphisms using a thymidine-based molecular beacon.
Biosensors & bioelectronics - 15 Apr 2009
Liu Chi-Wei, Lin Yang-Wei, Huang Chih-Ching, Chang Huan-Tsung
Abstract excerpt
We have developed a universal molecular beacon (T(7)-MB-T(7)) for the detection of single-nucleotide polymorphisms (SNPs). The beacon, which contains a 19-mer loop and a stem comprising a pair of seven thymidine (T) bases, forms double-stranded structures with target DNA molecules, leading to inc...
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