Article
[Significance of the TDP-43 deposition in FTLD-U and ALS].
Rinsho shinkeigaku = Clinical neurology - 1 Nov 2008
Hasegawa Masato, Arai Tetsuaki, Nonaka Takashi, Kametani Fuyuki, Yoshida Mari, Hashizume Yoshio, Beach Thomas G, Morita Mitsuya, Nakano Imaharu, Oda Tatsuro, Tsuchiya Kuniaki, Akiyama Haruhiko
Abstract excerpt
Tau-negative and ubiquitin-positive inclusions (UPI) are the pathological hallmarks of frontotemporal lobar degeneration (FTLD-U) and amyotrophic lateral sclerosis (ALS). Recently, TDP-43, a heterogeneous nuclear ribonucleoprotein was identified as a component of these UPI. However, it remains to be determined whether TDP-43 is the major component of UPI, because only antibodies recognizing both normal and...
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