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Article

Discrimination of HLA null and low expression alleles by cytokine-induced secretion of recombinant soluble HLA.

Molecular immunology - 1 Apr 2009

Hinrichs Jan, Figueiredo Constança, Hirv Kaimo, Mytilineos Joannis, Blasczyk Rainer, Horn Peter A, Eiz-Vesper Britta

Abstract excerpt

The disruption of disulfide bridges can decrease or abolish the cell surface expression of HLA class I molecules. Such disulfide bridges are formed by cysteine residues between amino acid (aa) positions 101/164 (alpha(2) domain) and 203/259 (alpha(3) domain). Sequence alterations in codons 101, 164, 203 and 259 have been observed in eleven HLA-A molecules. All of these variants except of A*3014L and A*3211Q have...

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PMID: 19195705
DOI: 10.1016/j.molimm.2008.12.011

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TNF

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