Article
Aberrant expression of HLA-B*3565Q is associated with a disrupted disulfide bond.
Immunogenetics - 1 Nov 2006
Elsner Holger-Andreas, Horn Peter A, Schoenemann Constanze, Altermann Wolfgang W, Blasczyk Rainer
Abstract excerpt
The identification of expression variants is a challenge in HLA diagnostics. We here describe the identification of the novel allele HLA-B*3565Q. The serological HLA class I type, as determined by a lymphocytotoxicity test, was A11,24; B38; Bw4; Cw-; whereas PCR-sequence-specific primers resulted in A*11,*24, B*35,*38; Cw*12, thus suggesting the presence of a nonexpressed B*35 allele. To clarify the lack of...
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