Article
Polymorphic drug metabolizing CYP-enzymes--a pathogenic factor in oral lichen planus?
Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology - 1 Jan 2009
Kragelund C, Hansen C, Reibel J, Nauntofte B, Broesen K, Pedersen A M L, Smidt D, Eiberg H, Torpet L A
Abstract excerpt
BACKGROUND: Oral lichen planus (OLP) is a chronic mucosal disease with a characteristic clinical phenotype. Environmental exposures, e.g. drugs have been associated with the pathogenesis. OBJECTIVES: To test the hypothesis that some OLP lesions have a pharmacological pathogenesis related to polymorphisms of the cytochrome P450 enzymes (CYPs) resulting in poor or intermediate CYP metabolism. METHODS: One hundred...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.