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Article

Osteocalcin secretion as an early marker of in vitro osteogenic differentiation of rat mesenchymal stem cells.

Tissue engineering. Part C, Methods - 1 Jun 2009

Nakamura Akifumi, Dohi Yoshiko, Akahane Manabu, Ohgushi Hajime, Nakajima Hiroshi, Funaoka Hiroyuki, Takakura Yoshinori

Abstract excerpt

Osteocalcin (OC) is a bone-specific protein synthesized by osteoblasts that represents a good marker for osteogenic maturation. We examined whether in vitro osteogenic differentiation of rat bone marrow-derived mesenchymal stem cells (MSCs) could be simply assessed at earlier stages by monitoring OC secretion into the conditioned medium, rather than measuring OC deposition on the extracellular matrix (ECM), using...

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Identifiers

PMID: 19191495
DOI: 10.1089/ten.tec.2007.0334

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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