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Article

Arginine-induced germ tube formation in Candida albicans is essential for escape from murine macrophage line RAW 264.7.

Infection and immunity - 1 Apr 2009

Ghosh Suman, Navarathna Dhammika H M L P, Roberts David D, Cooper Jake T, Atkin Audrey L, Petro Thomas M, Nickerson Kenneth W

Abstract excerpt

The opportunistic fungal pathogen Candida albicans is a part of the normal flora but it also causes systemic candidiasis if it reaches the bloodstream. Upon being phagocytized by macrophages, an important component of innate immunity, C. albicans rapidly upregulates a set of arginine biosynthetic genes. Arginine, urea, and CO2 induced hyphae in a density-dependent manner in wild-type, cph1/cph1, and rim101/rim101...

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Identifiers

PMID: 19188358
DOI: 10.1128/IAI.01452-08
PMCID: PMC2663133

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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