Article
Searching for genotype-phenotype structure: using hierarchical log-linear models in Crohn disease.
American journal of human genetics - 1 Feb 2009
Chapman Juliet M, Onnie Clive M, Prescott Natalie J, Fisher Sheila A, Mansfield John C, Mathew Christopher G, Lewis Cathryn M, Verzilli Claudio J, Whittaker John C
Abstract excerpt
There has been considerable recent success in the detection of gene-disease associations. We consider here the development of tools that facilitate the more detailed characterization of the effect of a genetic variant on disease. We replace the simplistic classification of individuals according to a single binary disease indicator with classification according to a number of subphenotypes. This more accurately...
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