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Article

A multistage association study identifies a breast cancer genetic locus at NCOA7.

Cancer research - 1 Jun 2011

Higginbotham Kathryn S P, Breyer Joan P, Bradley Kevin M, Schuyler Peggy A, Plummer W Dale, Freudenthal Marcia E, Trentham-Dietz Amy, Newcomb Polly A, Sanders Melinda E, Page David L, Parl Fritz F, Egan Kathleen M, Dupont William D, Smith Jeffrey R

Abstract excerpt

Estrogen metabolism and growth factor signaling pathway genes play key roles in breast cancer development. We evaluated associations between breast cancer and tagging single-nucleotide polymorphisms (SNP) of 107 candidate genes of these pathways using single allele- and haplotype-based tests. We first sought concordance of associations between two study populations: the Nashville Breast Cohort (NBC; 510 cases,...

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Identifiers

PMID: 21610108
DOI: 10.1158/0008-5472.CAN-10-2653
PMCID: PMC3137260

Genes

NCOA7
FGFR2
EGFR

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