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Optimization of Transrenal DNA Analysis: Detection of Fetal DNA in Maternal Urine

31 Jan 2009

Abstract excerpt

BACKGROUND: Fragments of DNA from cells dying throughout the body are detectable in urine (transrenal DNA, or Tr-DNA). Our goal was the optimization of Tr-DNA isolation and detection techniques, using as a model the analysis of fetal DNA in maternal urine. METHODS: We isolated urinary DNA using a traditional silica-based method and using a new technique based on adsorption of cell-free nucleic acids on...

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Share to Prenatal Screening and Diagnostics
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PMID: 19181739
DOI: 10.1373/clinchem.2008.113050

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