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Optimized Real-Time Quantitative PCR Measurement of Male Fetal DNA in Maternal Plasma

15 Jul 2005

Abstract excerpt

BACKGROUND: Circulating fetal DNA (cfDNA) in maternal plasma has been measured to investigate its possible relationship with pregnancy-related disorders, including fetal trisomy 21 and preeclampsia. The circulating concentrations of single-copy fetal genes, however, are close to the detection limits of PCR methods. METHODS: We optimized a protocol for the real-time quantitative PCR amplification of the multicopy...

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PMID: 16020496
DOI: 10.1373/clinchem.2005.051235

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