Article
High resolution size analysis of fetal DNA in the urine of pregnant women by paired-end massively parallel sequencing.
PloS one - 1 Jan 2012
Tsui Nancy B Y, Jiang Peiyong, Chow Katherine C K, Su Xiaoxi, Leung Tak Y, Sun Hao, Chan K C Allen, Chiu Rossa W K, Lo Y M Dennis
Abstract excerpt
BACKGROUND: Fetal DNA in maternal urine, if present, would be a valuable source of fetal genetic material for noninvasive prenatal diagnosis. However, the existence of fetal DNA in maternal urine has remained controversial. The issue is due to the lack of appropriate technology to robustly detect the potentially highly degraded fetal DNA in maternal urine. METHODOLOGY: We have used massively parallel paired-end...
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