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Article

Induction of the proliferative phenotype in differentiated myogenic cells by hypoxia.

The Journal of biological chemistry - 25 Sept 1991

Butler A J, Eagleton M J, Wang D, Howell R L, Strauch A R, Khasgiwala V, Smith H C

Abstract excerpt

The effect of cellular differentiation on the response of cells to hypoxic stress has been evaluated using the myogenic cell line BC3H1. Aerobic myocytes were predominantly in G0/G1 of the cell cycle and could be induced into S and G2/M of the cell cycle only by replating in high serum-containing medium at subconfluent cell density. In contrast, hypoxic myocytes demonstrated marked progression into S and G2/M...

Topics

Animals
Autoradiography
Cell Cycle
Cell Differentiation
Cell Hypoxia
Cell Line
Cell Survival
Electrophoresis, Gel, Two-Dimensional
Mice
Muscle Proteins
Muscles

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Oxygen

Phenotype

Source

Identifiers

PMID: 1917953

Genes

GRP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1917953-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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