Article
Expressed full-length von Willebrand factor containing missense mutations linked to type IIB von Willebrand disease shows enhanced binding to platelets.
Blood - 15 Apr 1992
Kroner P A, Kluessendorf M L, Scott J P, Montgomery R R
Abstract excerpt
von Willebrand disease (vWD) variant type IIB is an inherited bleeding disorder resulting from the spontaneous binding of defective von Willebrand factor (vWF) to platelets in vivo. To identify the molecular basis for type IIB vWD, we used reverse transcription and the polymerase chain reaction t...
Topics
- Animals
- Base Sequence
- Blood Platelets
- Cloning, Molecular
- DNA
- Endothelium, Vascular
- Female
- Humans
- Leukocytes
- Male
- Molecular Sequence Data
- Mutation
- Oligonucleotides, Antisense
- Pedigree
- Platelet Membrane Glycoproteins
- Polymerase Chain Reaction
- Protein Binding
- RNA