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Article

Chromosomal location targets different MYC family gene members for oncogenic translocations.

Proceedings of the National Academy of Sciences of the United States of America - 17 Feb 2009

Gostissa Monica, Ranganath Sheila, Bianco Julia M, Alt Frederick W

Abstract excerpt

The MYC family of cellular oncogenes includes c-Myc, N-myc, and L-myc, which encode transcriptional regulators involved in the control of cell proliferation and death. Accordingly, these genes become aberrantly activated and expressed in specific types of cancers. For example, c-Myc translocations occur frequently in human B lymphoid tumors, while N-myc gene amplification is frequent in human neuroblastomas. The...

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Identifiers

PMID: 19174520
DOI: 10.1073/pnas.0812763106
PMCID: PMC2650145

Genes

MYC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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