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Article

[Site-directed modification of caspase cleavage site regions in avian influenza virus proteins].

Voprosy virusologii - 1 Jan 2000

Zhirnov O P, Syrtsev V V, Vorob'eva I V, Klenk H D

Abstract excerpt

A reverse genetics approach was applied to generate variants of avian influenza virus A/FPV/Ro/34 (H7N1) containing mutations in the caspase cleavage sites of NP and M2 proteins. Mutation Gly16 --> Asp in avian virus NP made this protein (NPgd) sensitive to caspases, like human virus NP, and permitted its cleavage in infected cells. Mutant recombinant virus NPgd was able to replicate and stably carried Gly -->...

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PMID: 19172901

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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