Article
The PrP genotype of sheep of the improved Valachian breed.
Folia microbiologica - 1 Jan 2003
Tkáciková L, Hanusovská E, Novák M, Arvayová M, Mikula I
Abstract excerpt
In a worldwide majority of sheep breeds an excessive susceptibility to scrapie associated with the PrP gene alleles coding for valine (V; at the 136 codon) and glutamine (Q; at the 171 codon) (e.g., VRQ/VRQ, VRQ/ARQ, or ARQ/ARQ) was demonstrated. Particularly the PrPVRQ allele is closely associated with the high-risk development of the disease; the PrPARQ allele can also fulfill this function but under certain...
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