Article
Haploinsufficiency of glutamine synthetase increases susceptibility to experimental febrile seizures.
Genes, brain, and behavior - 1 Apr 2009
van Gassen K L I, van der Hel W S, Hakvoort T B M, Lamers W H, de Graan P N E
Abstract excerpt
Glutamine synthetase (GS) is a pivotal glial enzyme in the glutamate-glutamine cycle. GS is important in maintaining low extracellular glutamate concentrations and is downregulated in the hippocampus of temporal lobe epilepsy patients with mesial-temporal sclerosis, an epilepsy syndrome that is frequently associated with early life febrile seizures (FS). Human congenital loss of GS activity has been shown to...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.