Effects of epistasis and the evolution of genetic architecture: exact results for a 2-locus model.

doi:10.1016/j.tpb.2008.12.003

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Article

Effects of epistasis and the evolution of genetic architecture: exact results for a 2-locus model.

Theoretical population biology - 1 Jan 2000

Alvarez-Castro José M, Kopp Michael, Hermisson Joachim

Abstract excerpt

We study a two-locus model of a quantitative trait with a continuum-of alleles and multilinear epistasis that evolves under mutation, selection, and genetic drift. We derive analytical results based on the so-called House of Gauss approximation for the genetic variance, the mean phenotype, and the mutational variance in the balance of the evolutionary forces. The analytical work is complemented by extensive...

Topics

Alleles
Biological Evolution
Computer Simulation
Epistasis, Genetic
Models, Genetic
Stochastic Processes

Source

Open in PubMed

Identifiers

PMID: 19167413
DOI: 10.1016/j.tpb.2008.12.003

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