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Article

Epistasis in polygenic traits and the evolution of genetic architecture under stabilizing selection.

The American naturalist - 1 May 2003

Hermisson Joachim, Hansen Thomas F, Wagner Günter P

Abstract excerpt

We consider the effects of epistasis in a polygenic trait in the balance of mutation and stabilizing selection. The main issues are the genetic variation maintained in equilibrium and the evolution of the mutational effect distribution. The model assumes symmetric mutation and a continuum of alleles at all loci. Epistasis is modeled proportional to pairwise products of the single-locus effects. A general...

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Identifiers

PMID: 12858280
DOI: 10.1086/374204

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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