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Article

Epistasis and natural selection shape the mutational architecture of complex traits.

Nature communications - 14 May 2014

Jones Adam G, Bürger Reinhard, Arnold Stevan J

Abstract excerpt

The evolutionary trajectories of complex traits are constrained by levels of genetic variation as well as genetic correlations among traits. As the ultimate source of all genetic variation is mutation, the distribution of mutations entering populations profoundly affects standing variation and genetic correlations. Here we use an individual-based simulation model to investigate how natural selection and gene...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 24828461
DOI: 10.1038/ncomms4709
PMCID: PMC4024485

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