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Article

High post surgical opioid requirements in Crohn's disease are not due to a general change in pain sensitivity.

European journal of pain (London, England) - 1 Nov 2009

Huehne Kathrin, Leis Stefan, Muenster Tino, Wehrfritz Andreas, Winter Stefanie, Maihöfner Christian, Foertsch Thomas, Croner Roland, Reis André, Winterpacht Andreas, Rautenstrauss Bernd

Abstract excerpt

Crohn's disease (CD) is a painful inflammatory bowel disease with complex multigenic inheritance. Suggested on the basis of a few isolated reports CD patients require significantly higher post operative opioid doses than patients undergoing comparable severe abdominal surgery. Crohn's disease therefore may be a suitable model for the identification of novel pain susceptibility genes. In order to confirm this...

Read the complete abstract on PubMed

Topics

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Share to Analgesics, Opioid
Share to Catechol O-Methyltransferase

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Nod2 Signaling Adaptor Protein

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Share to Pain, Postoperative

Share to Receptors, Opioid, mu

Source

Identifiers

PMID: 19167252
DOI: 10.1016/j.ejpain.2008.12.004

Genes

COMT
OPRM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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